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In this hearty bake, creamy spinach and tender orzo pasta create a hearty bed for spiced tilapia fillets. For a golden brown crust, we’re adding a layer of seasoned panko breadcrumbs in the last few minutes of baking.
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Place an oven rack in the center of the oven; preheat to 450°F. Fill a large pot 3/4 of the way up with salted water; cover and heat to boiling on high. Wash and dry the fresh produce. Halve, peel, and large dice the onion. Cut off and discard the stems of the peppers; remove the cores, then large dice. Place the diced onion and diced peppers in a baking dish. Drizzle with olive oil and season with salt and pepper; toss to coat. Arrange in an even layer. Bake 13 to 15 minutes, or until the vegetables are lightly browned and slightly tender when pierced with a fork. Leaving the oven on, remove from the oven.
Meanwhile, add the pasta to the pot of boiling water. Cook, stirring occasionally, 7 to 9 minutes, or until tender. Turn off the heat. Drain thoroughly and return to the pot. Add the spinach and a drizzle of olive oil; stir until combined and the spinach is wilted.
Meanwhile, pat the tilapia dry with paper towels; season on both sides with salt, pepper, and half the spice blend. Cut the butter into 4 equal-sized pieces. In a bowl, combine breadcrumbs, remaining spice blend, and 2 tablespoons of olive oil; season with salt and pepper.
Add the cooked pasta and spinach, crème fraîche, and vinegar to the baking dish of partially baked vegetables; season with salt and pepper. Stir to thoroughly combine. Taste, then season with salt and pepper if desired. Place the seasoned tilapia on top of the dressed pasta. Top each piece of tilapia with 1 piece of butter. Cover the baking dish with foil.
Bake the prepared tilapia and pasta 7 minutes. Leaving the oven on, remove from the oven. Carefully remove the foil. Evenly top the casserole with the seasoned breadcrumbs. Return to the oven and bake 7 to 9 minutes, or until the breadcrumbs are lightly browned and the tilapia is cooked through.* Remove from the oven. Let stand at least 2 minutes before serving.
Meanwhile, in a bowl combine the sour cream, relish, and as much of the hot sauce as you'd like, depending on how spicy you'd like the dish to be. Taste, then season with salt and pepper if desired. Serve the baked casserole topped with the sauce. Enjoy!
Tips from Home Chefs